Neuroprotective Effects of High-Intensity Interval Training through Neuroplastic Changes in a Restraint Stress-Induced Depression Model

This study aimed to analyze the neuroprotective effects of various exercise intensities in a mouse model depressive behavior disorders. Seven-week-old male C57BL/6 mice were divided into control group, disorder group (RST), moderate-intensity sustained (RST_MICT), high-intensity (RST_HICT), and interval (RST_HIIT). The animal was established by applying restraint stress (RST) at 2 h/day for 14 days. Behavioral function better all groups, especially RST_HIIT than RST group. Factors related brain-derived neurotrophic factor showed higher levels groups 4-hydroxynonenal, an oxidative index, significantly lower Malondialdehyde but difference not significant. analysis serotonin corticosterone, indicators depression, revealed positive results groups. neuroplasticity-related variables c-fos glial fibrillary acidic protein more Thus, HIIT improved neuroplasticity, stress, factors model, indicating its potential preventing treating depression.